Centrin depletion causes cyst formation and other ciliopathy-related phenotypes in zebrafish
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چکیده
منابع مشابه
Modeling seizure-related behavioral and endocrine phenotypes in adult zebrafish.
Larval zebrafish (Danio rerio) have recently been suggested as a high-throughput experimental model of epilepsy-related pathogenetic states. Here we use adult zebrafish to study behavioral symptoms associated with drug-evoked seizures. Experimental epilepsy-like states were evoked in zebrafish by exposure for 20min to three chemoconvulsant drugs: caffeine (250mg/L; 1.3mM), pentylenetetrazole (1...
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abstract: mineral scaling in oil and gas production equipment is one of the most important problem that occurs while water injection and it has been recognized to be a major operational problem. the incompatibility between injected and formation waters may result in inorganic scale precipitation in the equipment and reservoir and then reduction of oil production rate and water injection rate. ...
Assessing epilepsy-related behavioral phenotypes in adult zebrafish
Over the past decades, zebrafish have been presented as a novel and valuable tool for modeling complex human diseases. Epilepsy is a serious brain disorder with multiple genetic and environmental causes. Our poor understanding of its pathogenesis requires novel paradigms and model organism for translational experimental epilepsy research. Seizure-like behavior has already been studied in both l...
متن کاملZebrafish models to study drug abuse-related phenotypes.
Mounting evidence implicates the zebrafish (Danio rerio) as a promising model species for reward and addiction research. Modeling drug abuse-related behavior in both adult and larval zebrafish produced a wealth of clinically translatable data, also demonstrating their sensitivity to various drugs of abuse and the ability to develop tolerance. Several studies have also applied withdrawal paradig...
متن کاملDepletion of suppressor of cytokine signaling-1a causes hepatic steatosis and insulin resistance in zebrafish.
Suppressor of cytokine signaling-1a (SOCS1a) is a member of the suppressor of cytokine signaling family, a group of related molecules that mediate the negative regulation of the JAK-STAT pathway. Here, we depleted SOCS1a using the transcription activator-like (TAL) effector nuclease (TALEN) technique to understand its physiological roles in zebrafish. Although elevated levels of JAK-STAT5 activ...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2011
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.10.22.18150